HYPOLIPIDEMIC EFFECT OF Hibiscus sabdariffa ON HIGH FAT DIET INDUCED TYPE 2 DIABETES WISTAR RATS

Abstract

The study was conducted to assess the hypolipidemic effect of Hibiscus sabdariffa on high fat diet induced type 2 diabetes wistar rats. The plant also called roselle, a tropical plant, has been traditionally used in various cultures to treat hypertension, hyperlipidemia, and other ailments. The plant's calyces, leaves, and flowers have been reported to possess antioxidant, anti-inflammatory and hypolipidemic properties. Twenty (20) rats were grouped into five (5) groups with (4) rats per group. Group 1 (Normal Control) was maintained on normal rodent diet, group 2 (Negative Control) fed high fat diet, group 3, 4, and 5 were maintained on high fat diet with inclustion of 3%, 5%  and 7% respectively. The diets were formulated according to standard procedure. After eight weeks of feeding, the animals were weighed, anaesthetized using chloroform, sacrificed and blood samples were collected. The plasma was collected after centrifugation at 1500g for 15 minutes and taken to Federal Teaching Hospital Katsina for analysis according to Randox Laboratory Limited United Kingdom. All the raw data obtained in this research were statistically anlyzed using SPSS version 22 (considering P<0.05 to be significant) and values we're presented as mean plus or minus standard error. The result showed that administration of Hibiscuss sabdariffa significantly reduced triglycerides, total cholesterol, atherogenic index and coronary risk index levels while increasing HDL-C, although LDL-C levels did not show a significant decrease. These finding suggests that Hibiscus sabdariffa possesses potent hypolipidemic properties, which may be beneficial in managing dyslipidemia associated with type 2 diabetes. More work should be carried by varying the doses of Hibiscus sabdariffa so as to verify the better doses that can work.

KEYWORDS: Hibiscus sabdariffa, Type 2 Diabetes, hypolipidemic, hypertension, antioxidant, anti inflammatory.