UNDERSTANDING THE CRITICAL ROLE OF HIV PROTEASE IN PARTHOGENESIS: MOLECULAR MECHANISMS AND THERAPEUTIC IMPLICATIONS

Abstract

Human Immunodeficiency Virus (HIV) continues to pose significant global health challenges, with an estimated 38 million people living with the virus worldwide. Understanding the molecular intricacies of HIV protease is crucial for elucidating viral pathogenesis and developing effective therapeutic strategies. This review provides an overview of HIV and underscores the importance of comprehending HIV pathogenesis in combating the epidemic.

HIV protease, a key enzyme in the viral life cycle, plays a pivotal role in cleaving viral polyproteins, thus facilitating viral maturation and enhancing infectivity. Additionally, HIV protease contributes to immune system evasion through its molecular mechanisms, including substrate specificity, interactions with other viral proteins, and host cell interactions.

Current antiretroviral drugs targeting HIV protease have reportedly improved patient outcomes; however, drug resistance remains a challenge. Ongoing advancements in drug development and potential future therapeutic strategies hold promise for overcoming these challenges. Moreover, understanding the clinical implications of HIV protease, including drug resistance and its impact on patient outcomes, is vital for informing clinical research directions.

In conclusion, ongoing research into HIV protease is essential for developing novel therapeutic approaches and addressing the evolving challenges posed by HIV/AIDS. This review highlights the critical role of HIV protease in viral pathogenesis and emphasizes the importance of continued efforts in this field.

Keywords: HIV, protease, pathogenesis, antiretroviral drugs, drug resistance, therapeutic strategies, clinical implications