HYPOLIPIDEMIC POTENTIAL OF CARICA PAPAYA LEAF EXTRACT ON RAT LIVER FED WITH COW BRAIN TISSUE

Abstract

Hyperlipidemia is the major contributor to cardiovascular disease (CVD). This study investigates the hypolipidemic potential of methanol extract of Carica papaya leaf on the liver of albino rats fed with formulated cow brain tissue. Thirty five (35) albino rats were divided into seven groups of five rats each. Group I (ND) served as the positive control, group III (FHD) is negative control, group II (ND+62mg/dl) was pretreated before the induction, IV, V and VI were induced with FHD and treated with 31, 62 and 124mg/dl of methanol extract of C.papaya leaf expectively, Group VII (Ator) was induced with formulated cow brain tissue and treated with atorvastatin, the experiment was carried out for the period of 28 days. Biochemical analysis showed that induction of formulated cow brain tissue significantly elevated serum lipid profile with the exception of HDL, and siginificantly increased HDL level, when compared the effect of C.papaya extract with atorvastatin, the C.papaya were mostly effective in all the treated groups. The observed hypolipidemic effects maybe due to the presence of phytochemicals such as saponins and flavonoids which may inflect lipid metabolism and inhibit HMG-CoA reductase activity. These findings suggest that the C. papaya leaf extract could be considered, along with other lifestyle changes, as an alternative treatment for hyperlipidemic patients.

Keywords: Hyperlipidemia, Cardiovascular disease, C.papaya, HMG-CoA reductase, ND, FHD.