Invitro study of the interaction between Ampicillin and Cloxacillin in Ampiclox dry syrup in five different brands of Ampiclox in Lagos market

Abstract

There have been indications that interactions exist between ampicillin and cloxacillin in all the brands of Ampiclox in the Nigerian market. Even from the analyst point of view, sometimes in trying to recover cloxacillin from the mixture, the result is usually not consistent and unreliable. The concentration at which this interaction exist hasnot been ascertain. Also, since various people of different age and size use the antibiotic because of its wide spectrum. There is the need to find out the range of concentration at which interaction sets in.

The is research involves five different brands from Lagosmarket. The brands were mixed at different concentrations and analyzed using British pharmacopeia method of 1998.

The results show that administering the same dose ofAmpiclox within children of the same age and of different sizes can result into drug interaction in vivo or in their system. This is because they possess different volume of distribution.it has been known that children or neonates with small volume of distribution experience drug interaction when given the dose -0.125g in volume below 200cm3.